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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
19.39
Human Site:
S1294
Identified Species:
30.48
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S1294
G
E
E
A
L
T
P
S
V
P
I
N
K
G
P
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1302
G
E
E
A
L
T
P
S
V
P
I
N
K
G
P
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1288
G
E
E
A
L
I
P
S
A
P
I
N
K
G
P
Dog
Lupus familis
XP_534241
2041
231068
S1712
G
E
E
A
L
I
P
S
A
P
V
N
K
G
P
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S1282
G
E
E
T
L
T
P
S
A
P
V
N
K
G
P
Rat
Rattus norvegicus
P41516
1526
173202
I1217
S
P
V
G
K
R
V
I
P
Q
V
T
M
E
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
A1598
E
D
P
L
N
T
S
A
P
V
P
K
T
P
K
Chicken
Gallus gallus
O42131
1627
183228
A1300
G
D
D
T
V
N
T
A
A
S
G
T
K
T
P
Frog
Xenopus laevis
NP_001082502
1579
178601
T1266
E
Q
S
P
E
G
L
T
L
A
E
R
L
S
K
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
G1293
N
S
L
I
S
P
S
G
L
P
N
P
G
A
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
K1138
M
W
M
L
T
E
E
K
K
N
E
L
L
K
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
W1211
R
V
I
E
K
K
T
W
Q
D
L
W
H
E
D
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
S1139
F
D
D
A
A
S
D
S
S
E
A
G
S
G
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
E1164
S
L
W
L
S
D
L
E
S
L
D
K
E
L
E
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
M1119
T
Y
E
Y
L
L
G
M
R
I
W
S
L
T
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
86.6
80
N.A.
80
0
N.A.
6.6
20
0
6.6
N.A.
0
N.A.
0
26.6
P-Site Similarity:
100
100
86.6
86.6
N.A.
86.6
6.6
N.A.
20
46.6
20
13.3
N.A.
0
N.A.
6.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
34
7
0
0
14
27
7
7
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
20
14
0
0
7
7
0
0
7
7
0
0
0
7
% D
% Glu:
14
34
40
7
7
7
7
7
0
7
14
0
7
14
7
% E
% Phe:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
40
0
0
7
0
7
7
7
0
0
7
7
7
40
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
7
7
0
14
0
7
0
7
20
0
0
0
0
% I
% Lys:
0
0
0
0
14
7
0
7
7
0
0
14
40
7
27
% K
% Leu:
0
7
7
20
40
7
14
0
14
7
7
7
20
7
0
% L
% Met:
7
0
7
0
0
0
0
7
0
0
0
0
7
0
7
% M
% Asn:
7
0
0
0
7
7
0
0
0
7
7
34
0
0
0
% N
% Pro:
0
7
7
7
0
7
34
0
14
40
7
7
0
7
47
% P
% Gln:
0
7
0
0
0
0
0
0
7
7
0
0
0
0
7
% Q
% Arg:
7
0
0
0
0
7
0
0
7
0
0
7
0
0
0
% R
% Ser:
14
7
7
0
14
7
14
40
14
7
0
7
7
7
0
% S
% Thr:
7
0
0
14
7
27
14
7
0
0
0
14
7
14
0
% T
% Val:
0
7
7
0
7
0
7
0
14
7
20
0
0
0
0
% V
% Trp:
0
7
7
0
0
0
0
7
0
0
7
7
0
0
0
% W
% Tyr:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _